We report the identification of a recurrent, 520-kb 16p12.1 microdeletion associated with childhood developmental delay. The microdeletion was detected in 20 of 11,873 cases compared with 2 of 8,540 controls and replicated in a second series of 22 of 9,254 cases compared with 6 of 6,299 controls. Most deletions were inherited, with carrier parents likely to manifest neuropsychiatric phenotypes compared to non-carrier parents. Probands were more likely to carry an additional large copy-number variant when compared to matched controls. The clinical (...) features of individuals with two mutations were distinct from and/or more severe than those of individuals carrying only the co-occurring mutation. Our data support a two-hit model in which the 16p12.1 microdeletion both predisposes to neuropsychiatric phenotypes as a single event and exacerbates neurodevelopmental phenotypes in association with other large deletions or duplications. Analysis of other microdeletions with variable expressivity indicates that this two-hit model might be more generally applicable to neuropsychiatric disease. © 2010 Nature America, Inc. All rights reserved. (shrink)

“Tell me," Wittgenstein once asked a friend, "why do people always say, it was natural for man to assume that the sun went round the earth rather than that the earth was rotating?" His friend replied, "Well, obviously because it just looks as though the Sun is going round the Earth." Wittgenstein replied, "Well, what would it have looked like if it had looked as though the Earth was rotating?” What would it have looked like if we looked at all (...) sciences from the viewpoint of Wittgenstein’s philosophy? Wittgenstein is undoubtedly one of the most influential philosophers of the twentieth century. His complex body of work has been analysed by numerous scholars, from mathematicians and physicists, to philosophers, linguists, and beyond. This volume brings together some of his central perspectives as applied to the modern sciences and studies the influence they may have on the thought processes underlying science and on the world view it engenders. The contributions stem from leading scholars in philosophy, mathematics, physics, economics, psychology and human sciences; all of them have written in an accessible style that demands little specialist knowledge, whilst clearly portraying and discussing the deep issues at hand. (shrink)

Much philosophical attention has been devoted to “The Land Ethic,” especially by Anglo-American philosophers, but little has been paid to A Sand County Almanac as a whole. Read through the lens of continental philosophy, A Sand County Almanac promulgates an evolutionary-ecological world view and effects a personal self- and a species-specific Self-transformation in its audience. It’s author, Aldo Leopold, realizes these aims through descriptive reflection that has something in common with phenomenology-although Leopold was by no stretch of the imagination a (...) phenomenologist. Consideration of human-animal intersubjectivity, thematized in A Sand County Almanac, brings to light the moral problem of hunting and killing animal subjects. Leopold does not confront that problem, but it is confronted and resolved by Jose Ortega y Gassett, Henry Beston, and Paul Shepard in terms of an appropriate human relationship with wild-animal Others. Comparison with the genuinely Other-based Leopold-Ortega-Beston-Shepard wild-animal ethic shows the purportedly Other-based humanand possibly animal ethic of Emmanuel Levinas actually to be Same-based after all. (shrink)

The hypothesis that high levels of religiosity are partly caused by high disease loads is in accord with studies showing that societal dysfunction promotes mass supernaturalism. However, some cultures suffering from high rates of disease and other socioeconomic dysfunction exhibit low levels of popular religiosity. At this point, it appears that religion is hard pressed to thrive in healthy societies, but poor conditions do not always make religion popular, either.

Historically, there has been widespread acceptance of the claim that religious belief – and, in particular, theistic belief – is essential to human flourishing, both for human individuals and for human societies. With the relatively recent rise of prosperous secular democracies, it is possible to put this claim to empirical test. When we do, we find no support for the claim that theistic belief is essential to human flourishing, and significant support for the claim that theistic belief impacts negatively on (...) human flourishing. (shrink)

The naturalist and geologist Charles Darwin ranks as one of the most influential scientific thinkers of all time. In the nineteenth century his ideas about the history and diversity of life - including the evolutionary origin of humankind - contributed to major changes in the sciences, philosophy, social thought and religious belief. This volume provides the reader with clear, lively and balanced introductions to the most recent scholarship on Darwin and his intellectual legacies. A distinguished team of contributors examines Darwin's (...) main scientific ideas and their development; Darwin's science in the context of its times; the influence of Darwinian thought in recent philosophical, social and religious debate; and the importance of Darwinian thought for the future of naturalist philosophy. New readers will find this a most convenient and accessible guide to Darwin. Advanced students and specialists will find a conspectus of recent developments in the interpretation of Darwin. (shrink)

The full extent of the anguish and death suffered by immature humans is scientifically and statistically documented for the first time. Probably hundreds of billions of human conceptions and at least fifty billion children have died, the great majority from nonhuman causes, before reaching the age of mature consent. Adults who have heard the word of Christ number in the lower billions. If immature deceased humans are allowed into heaven, then the latter is inhabited predominantly by automatons. Because the Holocaust (...) of the Children bars an enormous portion of humans from making a decision about their eternal fate while maximizing the suffering of children, the classic Christian “free will” and “best of all possible worlds” hypotheses are falsified. (shrink)

A vital and timely reminder that modern life owes as much to outlandish thinking as to dominant ideologies What do the Nag Hammadi library, Dan Brown's The Da Vinci Code, speculative feminist historiography, Marcus Garvey's finances, and maps drawn by asylum patients have in common? Jonathan P. Eburne explores this question as never before in Outsider Theory, a timely book about outlandish ideas. Eburne brings readers on an adventure in intellectual history that stresses the urgency of taking seriously--especially in (...) an era of fake news--ideas that might otherwise be discarded or regarded as errant, unfashionable, or even unreasonable. Examining the role of such thinking in contemporary intellectual history, Eburne challenges the categorical demarcation of good ideas from flawed, wild, or bad ones, addressing the surprising extent to which speculative inquiry extends beyond the work of professional intellectuals to include that of nonprofessionals as well, whether amateurs, unfashionable observers, or the clinically insane. Considering the work of a variety of such figures--from popular occult writers and gnostics to so-called outsider artists and pseudoscientists--Eburne argues that an understanding of its circulation and recirculation is indispensable to the history of ideas. He devotes close attention to ideas and texts usually omitted from or marginalized within orthodox histories of literary modernism, critical theory, and continental philosophy, yet which have long garnered the critical attention of specialists in religion, science studies, critical race theory, and the history of the occult. In doing so he not only sheds new light on a fascinating body of creative thought but also proposes new approaches for situating contemporary humanities scholarship within the history of ideas. However important it might be to protect ourselves from "bad" ideas, Outsider Theory shows how crucial it is for us to know how and why such ideas have left their impression on modern-day thinking and continue to shape its evolution. (shrink)

In On the Origin of Species, Charles Darwin put forward his theory of natural selection. Conventionally, Darwin's argument for this theory has been understood as based on an analogy with artificial selection. But there has been no consensus on how, exactly, this analogical argument is supposed to work – and some suspicion too that analogical arguments on the whole are embarrassingly weak. Drawing on new insights into the history of analogical argumentation from the ancient Greeks onward, as well as on (...) in-depth studies of Darwin's public and private writings, this book offers an original perspective on Darwin's argument, restoring to view the intellectual traditions which Darwin took for granted in arguing as he did. From this perspective come new appreciations not only of Darwin's argument but of the metaphors based on it, the range of wider traditions the argument touched upon, and its legacies for science after the Origin. (shrink)

If “Big Gods” evolved in part because of their ability to morally regulate groups of people who cannot count on kin or reciprocal altruism to get along, then powerful gods would tend to be good gods. If the mechanism for this cooperation is some kind of fear of supernatural punishment, then we may expect that mighty gods tend to be punishing gods. The present study is a statistical analysis of superhuman being concepts from 20 countries on five continents to explore (...) whether the goodness of a god is related to its mightiness. Gods that looked more like the God of classical theism and gods that were low in anthropomorphism were more likely to be regarded as morally good and to be the target of religious practices. Mighty gods were not, however, especially likely to punish or to be a “high god.”. (shrink)

As part of a review symposium on DARWIN'S ARGUMENT BY ANALOGY: FROM ARTIFICIAL TO NATURAL SELECTION (2021), the journal METASCIENCE invited Roger White, Jon Hodge and me to submit a response to the thoughtful commentaries on our book by Andrea Sullivan-Clarke, David Depew and Andrew Inkpen.

The use of contingent valuation methods for estimating the economic value of environmental improvements and damages has increased significantly. However, doubts exist regarding the validity of the usual willingness to pay CV methods. In this article, we examine the CV approach in light of recent findings from behavioral decision research regarding the constructive nature of human preferences. We argue that a principal source of problems with conventional CV methods is that they impose unrealistic cognitive demands upon respondents. We propose a (...) new CV approach, based on the value-structuring capabilities of multiattribute utility theory and decision analysis, and discuss its advantages and disadvantages. (shrink)

W. V. Quine was the most important naturalistic philosopher of the twentieth century and a major impetus for the recent resurgence of the view that empirical science is our best avenue to knowledge. His views, however, have not been well understood. Critics charge that Quine’s naturalized epistemology is circular and that it cannot be normative. Yet, such criticisms stem from a cluster of fundamental traditional assumptions regarding language, theory, and the knowing subject – the very presuppositions that Quine is at (...) pains to reject. Through investigation of Quine’s views regarding language, knowledge, and reality, the author offers a new interpretation of Quine’s naturalism. The naturalism/antinaturalism debate can be advanced only by acknowledging and critiquing the substantial theoretical commitments implicit in the traditional view. Gregory argues that the responses to the circularity and non-normativity objections do just that. His analysis further reveals that Quine’s departure from the tradition penetrates the conception of the knowing subject, and he thus offers a new and engaging defence of Quine’s naturalism. (shrink)

At a time when many international relations scholars are qualifying their premature predictions of the withering of the state, Daniel Drezner's new book makes a compelling case for the continued centrality of the state in the process of globalization.

The human brain does not use more energy than the smaller brains of animals of comparable corporal weight. Uniquely, human functions localized largely in parts of the human brain that show greatest size increase over other animals may be mediated primarily by nonsynaptic neurotransmission, with reduced energy cost per kilogram of brain. This may affect the energetic constraints on evolution.

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:The Eucharistic Form of God: Trinity, Incarnation, and Sacrament in the Theology of Hans Urs von Balthasar by Jonathan Martin CirauloNicholas J. HealyThe Eucharistic Form of God: Trinity, Incarnation, and Sacrament in the Theology of Hans Urs von Balthasar. By Jonathan Martin Ciraulo. Notre Dame, Ind.: University of Notre Dame Press, 2022. Pp. xiii + 297. $50.00 (hardcover). ISBN: 978-0-268-20223-1.In Fides et Ratio 93, under the (...) heading “current tasks for theology,” John Paul II writes:The chief purpose of theology is to provide an understanding of Revelation and the content of faith. The very heart of theological enquiry will thus be the contemplation of the mystery of the Triune God. The approach to this mystery begins with reflection upon the mystery of the Incarnation of the Son of God: his coming as man, his going to his Passion and Death.... From this vantage-point, the prime commitment of theology is seen to be the understanding of God’s kenosis, a grand and mysterious truth for the human mind, which finds it inconceivable that suffering and death can express a love which gives itself and seeks nothing in return. In this light, a careful analysis of texts emerges as a basic and urgent need: first the texts of Scripture, and then those which express the Church’s living Tradition. On this score, some problems have emerged in recent times, problems which are only partially new; and a coherent solution to them will not be found without philosophy’s contribution.These words about the mystery of Jesus Christ’s life and death as a revelation of the Triune God—and about the emergence of new difficulties and questions—underscore the importance of a dialogue between St. Thomas Aquinas and the great twentieth-century theologian Hans Urs von Balthasar. As two recent books written from a Thomistic perspective have shown (Aidan Nicholas, Balthasar for Thomists [San Francisco: Ignatius Press, 2020]); [End Page 715] Matthew Levering, The Achievement of Hans Urs von Balthasar [Washington, D.C.: The Catholic University of America Press, 2019]), Balthasar’s profound indebtedness to the metaphysics of Aquinas provides a solid foundation for dialogue. And yet a number of difficulties remain. What is the relationship between the so-called real distinction of esse and essence and the hypostatic union of two natures in the person of the Son? How and in what sense does the paschal mystery of Jesus’s death and Resurrection presuppose and express the mystery of the Father’s eternal generation of the Son? In the words of Joseph Ratzinger, “in the pierced heart of the Crucified, God’s own heart is opened up—here we see who God is and what he is like” (Spirit of the Liturgy [San Francisco: Ignatius Press, 2000], 48). How does the mystery of Christ’s Eucharist reveal the heart of God?This last question about the Eucharist and the nature of God is explored in depth in Jonathan Martin Ciraulo’s monograph, The Eucharistic Form of God: Hans Urs von Balthasar’s Sacramental Theology. Despite the expansive title, the primary aim of this book is fairly straightforward: to present Balthasar’s theology of the Eucharist and to show the significance of his thought for contemporary sacramental theology. Anyone who seeks to offer a systematic account of Balthasar’s theology of the Eucharist is confronted with at least two basic obstacles or challenges. First, his reflections on the Eucharist are scattered throughout (and often hidden within) an immense and complex corpus of writings. Second, the most distinctive feature of Balthasar’s theology of the Eucharist is the inseparability of his sacramental theology from his speculative account of the central mysteries of the Christian faith—Trinity, Incarnation, Cross and Resurrection, Church, and eschaton.The Eucharistic Form of God represents a thoughtful, well-written, and original response to this twofold challenge. Regarding the first point: Ciraulo demonstrates an intimate familiarity with the whole of Balthasar’s corpus. He draws together Balthasar’s early writings on German literature, his monographs on Origen, Gregory of Nyssa, and Maximus the Confessor, his engagement with Karl Barth, his interpretation of twentieth-century French Catholic literature... (shrink)

The unexpected roles of the microbiota in cancer challenge explanations of carcinogenesis that focus on tumor-intrinsic properties. Most tumors contain bacteria and viruses, and the host’s proximal and distal microbiota influence both cancer incidence and therapeutic responsiveness. Continuing the history of cancer–microbe research, these findings raise a key question: to what extent is the microbiota relevant for clinical oncology? We approach this by critically evaluating three issues: how the microbiota provides a predictive biomarker of cancer growth and therapeutic responsiveness, the (...) microbiota’s causal role(s) in cancer development, and how therapeutic manipulations of the microbiota improve patient outcomes in cancer. Clarifying the conceptual and empirical aspects of the cancer-associated microbiota can orient future research and guide its implementation in clinical oncology. (shrink)

International institutions are being transformed by the twinned appearance of new non-governmental organizations (NGOs) and new technologies. How do these processes co-evolve? If we were limited to three words to describe the new interactive technologies of the Web, we would highlight the following logics: link, search, interact. Whereas in other systems these logics are additive, on the Web they can be recombinatory. Search, for example, can be conducted based on the structure of links, leading to new patterns of interaction, new (...) links and new methods of search. Of greatest interest are the kinds of search where you don’t know what you’re looking for but will recognize it when you find it. In short, innovation is promoted by networked organizational forms. New technologies do not determine these innovative outcomes, but they can facilitate them. The article explores the prospect of shifts among NGOs from autarky to collaboration, and from information transmission to knowledge networks in the virtual public sphere. (shrink)

The recent phenomenon of the export zone attracts scholarly attention primarily for its economic and political logics, yet it is as a cultural phenomenon that the Zone may ultimately signal its transformational role in the trajectory of state sovereignty and the global urban imagination. This article approaches the phenomenon of the Zone as a key location for understanding the social and cultural impact of globalization on urban space. It conceptually locates the trajectory of the export-oriented zone and its analogues to (...) understand how, in little over 40 years, the phenomenon of the Zone experienced a rapid and veritable institutionalization as part of the topography and imagination of globalization. The first part traces the contours of the Zone as a territorial strategy that re-scales national economic and political space and enables the networked models of distributed production so critical to the global economy. The second part critically supplements the standard account by re-thinking the Zone as an incipient urban form — the Ex-City — that incorporates classically modernist fantasies in the context of contemporary logics of sovereignty and accumulation. (shrink)

Clinical Ethics, Ahead of Print. This paper is a response to a recent BMJ Blog: ‘The duty to treat: where do the limits lie?’ Members of the Surrey Heartlands Integrated Care Service Clinical Ethics Group reflected on arguments in the Blog in relation to resuscitation during the COVID-19 pandemic.Clinicians have had to contend with ever-changing and conflicting guidance from the Resuscitation Council UK and Public Health England regarding personal protective equipment requirements in resuscitation situations. St John Ambulance had different guidance (...) for first responders.The situation regarding resuscitation led the CEG to consider ethical aspects of health care professionals’ responses to the need for resuscitation during COVID-19. Members agreed that professionals should, ideally, have the level of PPE required for an aerosol generating procedure. However, there was no consensus regarding professionals’ duty to care when this is not available. On the one hand, it was agreed that the casualty/patient’s interests regarding resuscitation should be prioritised due to professionals’ contract with the public and professional privilege. On the other hand, risk thresholds were considered relevant to individual decision-making and professionals’ duty to care. All agreed that decision-making should not be influenced by rewards or reprimands. It was agreed also that decisions to resuscitate should not be considered as moral heroism or supererogatory - regardless of PPE availability - but rather as ‘minimally decent’. We agreed that it may be acceptable for professionals, with good reasons, to opt out of resuscitation attempts and these should be reflected on and discussed before the event. (shrink)

Guilt is a powerful emotion that is known to influence ethical decision-making. Nevertheless, the role of guilt cognitions in influencing restorative behaviour following an unethical action is not well understood. Guilt cognitions are interrelated beliefs about an individual’s role in a negative event. We experimentally investigate the joint impact of three guilt cognitions—responsibility for a decision, justification for a decision, and foreseeability of consequences—on a taxpayer’s decision to make a tax amnesty disclosure. Tax amnesties encourage delinquent taxpayers to self-correct to (...) avoid severe penalties that would result if their tax evasion were discovered. Our findings suggest a three-way interaction effect such that taxpayers are likely to make tax amnesty disclosures when they foresee that they will be caught by the tax authority, unless they can diffuse responsibility for their evasion and justify their evasion. Implications for tax policy and tax professionals are discussed. (shrink)

The recent interest of cognitive- and neuro-scientists in the topic of consciousness (and the dissatisfaction with the present state of knowledge) has revealed deep conceptual differences with Humanists, who have dealt with issues of consciousness for centuries. O'Regan & Noë have attempted (unsuccessfully) to bridge those differences.

PHIL 102 - Problems of Philosophy (Fall) This course has two main goals: first, to cultivate students’ critical attitude towards reading, writing, and daily life; second, to engage students with primary philosophical texts. Plato, Descartes, Locke, Hume, Peirce, Russell, Paley, Perry, Sagan, Ayer, Chisholm, and Dennett are among the authors I have used. Each week students are responsible for readings and reading questions to be answered out of class or in small in-class groups. These assignments are designed to develop critical (...) writing and thinking skills, focus students’ reading, and prompt students to actively engage the text prior to lecture and open discussion. Essay exams or short papers are used for assessment. Sample syllabus. (shrink)

In the fourth Immanuel Kant Lecture, Quine summons the specter of Kant’s Ding an sich, the thing in itself. Clearly antithetical to his naturalism, Quine quickly dismisses it as having feet of clay. Despite this short shrift, it is worth examining what he did say about the Ding an sich—in the Kant Lectures, in “Things and Their Place in Theories”, and in “Structure and Nature”. I offer a critical reading of these passages in the context of Quine’s proxy functions, ontological (...) relativity, and structure. I argue that Quine uses the Ding an sich as a foil for his anti-metaphysical, deflationary structuralism—a view that grounds objectivity in true statements, without any transcendental notion of objects, without the Ding an sich. (shrink)

This book investigates the anti-Semitic foundations of Nazi curricula for elementary schools, with a focus on the subjects of biology, history, and literature. Gregory Paul Wegner argues that any study of Nazi society and its values must probe the education provided by the regime. Schools, according to Wegner, play a major role in advancing ideological justifications for mass murder, and in legitimizing a culture of ethnic and racial hatred. Using a variety of primary sources, Wegner provides a vivid (...) account of the development of Nazi education. (shrink)

Through emotionally charged portraits and richly layered interior views, the photographs of Chicago-based artist Paul D Amato provide a genuine and complex perspective on life in some of the most challenging and troubled neighborhoods in the nation. This publication is supported in part by grants from the David C. and Sarajean Ruttenberg Arts Foundation and the Robert Mapplethorpe Foundation.".